细菌
大肠杆菌
活性氧
抗菌活性
多重耐药
光热治疗
金黄色葡萄球菌
催化作用
组合化学
体内
材料科学
纳米技术
微生物学
化学
抗生素
生物
生物化学
生物技术
基因
遗传学
作者
Jingyang Shan,Kangkang Yang,Weijun Xiu,Qiu Qiu,Sulai Dai,Lihui Yuwen,Lixing Weng,Zhaogang Teng,Lianhui Wang
出处
期刊:Small
[Wiley]
日期:2020-09-06
卷期号:16 (40)
被引量:106
标识
DOI:10.1002/smll.202001099
摘要
Abstract Nanozymes with unique enzyme‐like catalytic properties and versatile functionalities are particularly attractive for the treatment of bacterial infections, especially for combating drug‐resistant bacteria. However, inherently low catalytic activity significantly limits their antibacterial performance. Herein, a new near‐infrared II (NIR‐II) light responsive nanozyme (Cu 2 MoS 4 nanoplates, CMS NPs) is developed for efficient eradication of multidrug‐resistant (MDR) bacteria. CMS NPs with intrinsic dual enzyme‐like property can generate reactive oxygen species (ROS) by catalysis. Importantly, CMS NPs show NIR‐II light enhanced oxidase‐ and peroxidase‐like catalytic activities to improve ROS generation for highly efficient killing of bacteria. In vitro results demonstrate that CMS NPs (40 µg mL −1 ) achieve rapid killing of 8 log MDR Escherichia coli and 6 log MDR Staphylococcus aureus ( S. aureus ) under NIR‐II light irradiation (1064 nm, 1 W cm −2 ) in 10 min. Moreover, CMS NPs exhibit excellent therapeutic efficacy of MDR S. aureus infection in vivo as well as negligible toxicity to cells and animals, indicating their potential use as antibacterial agents. This work provides a novel antibacterial strategy by combining the catalytic generation of ROS and NIR‐II photothermal effect of nanozymes for efficient treatment of MDR bacteria‐related infections.
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