先天免疫系统
生物
秀丽隐杆线虫
免疫系统
免疫
神经科学
机制(生物学)
神经系统
抗菌肽
获得性免疫系统
免疫学
抗菌剂
微生物学
遗传学
基因
认识论
哲学
作者
Xiu Mei Zhang,Jie Gao,Chun Hong Chen,Hai Jun Tu
出处
期刊:PubMed
日期:2018-12-20
卷期号:40 (12): 1066-1074
标识
DOI:10.16288/j.yczz.18-133
摘要
The innate immune system is an important defense barrier against invasive microbial threats in plants and animals. The nematode worm Caenorhabditis elegans is a classic model to investigate the genetic and cellular mechanisms of the interaction between host and pathogens. In the past years, many studies have elucidated the machinery of host-pathogen interactions using C. elegans. Neurons secrete/release neuropeptides and neurotransmitters such as NLP-20 and dopamine, which in turn mediate microbial recognition, promote pathogen avoidance, activate innate immune response signaling to stimulate antimicrobial peptide expression and kill microbes, and ultimately protect organisms from pathogen infection. In this review, we summarize the recent advances in the mechanisms of neural modulation of innate immunity in C. elegans, which provide important knowledge not only for machinery of functional interaction between nervous and immune system, but also for pathological mechanisms of nervous and immune system related diseases.
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