长寿
亮氨酸
缬氨酸
异亮氨酸
氨基酸
内分泌学
健康衰老
内科学
老年学
医学
生物
寿命
遗传学
生物化学
作者
Nicole E. Richardson,Elizabeth N. Konon,Haley S. Schuster,Alexis T. Mitchell,Colin Boyle,Allison Rodgers,Megan Finke,Lexington R. Haider,Deyang Yu,Victoria Flores,Heidi H. Pak,Soha Ahmad,Sareyah Ahmed,Abigail B. Radcliff,Jing Wu,Evelyn W. Williams,Lovina Abdi,Dawn S. Sherman,Timothy A. Hacker,Dudley W. Lamming
出处
期刊:Nature Aging
日期:2021-01-14
卷期号:1 (1): 73-86
被引量:140
标识
DOI:10.1038/s43587-020-00006-2
摘要
Protein restricted (PR) diets promote health and longevity in many species. While the precise components of a PR diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of PR can be attributed to reduced dietary levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine. Here, we demonstrate that restricting dietary BCAAs increases the survival of two different progeroid mouse models, delays frailty and promotes the metabolic health of wild-type C57BL/6J mice when started in midlife, and leads to a 30% increase in lifespan and a reduction in frailty in male, but not female, wild-type mice when fed lifelong. Our results demonstrate that restricting dietary BCAAs can increase healthspan and longevity in mice, and suggest that reducing dietary BCAAs may hold potential as a translatable intervention to promote healthy aging.
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