明胶
生物粘附
差示扫描量热法
肿胀 的
自愈水凝胶
化学
药物输送
医学
高分子化学
病理
生物化学
有机化学
热力学
物理
作者
Roberta Cassano,Federica Curcio,Delia Mandracchia,Adriana Trapani,Sonia Trombino
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2020-06-27
卷期号:17 (4): 303-311
被引量:8
标识
DOI:10.2174/1567201817666200129130031
摘要
Aim: The work’s aim was the preparation and characterization of a hydrogel based on gelatin and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate the inflammatory process typical of the vaginal infection. Objective: The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM) and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel exhibits a relevant mucoadhesive activity. Methods: The swelling degree was evaluated at two different pHs and at defined time intervals. In particular, phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate the physiological environment. Results: The obtained results revealed that the hydrogel swells up well at both pHs. Conclusion: Release studies conducted at both pathological and physiological pHs have shown that benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal mucosa.
科研通智能强力驱动
Strongly Powered by AbleSci AI