医学
信号转导
肾
缺血
再灌注损伤
急性肾损伤
p38丝裂原活化蛋白激酶
肾缺血
体外冲击波碎石术
激酶
发病机制
丝裂原活化蛋白激酶
药理学
内科学
MAPK/ERK通路
生物
细胞生物学
外科
碎石术
标识
DOI:10.3760/cma.j.issn.1008-1372.2016.10.048
摘要
Renal ischemia reperfusion injury, a common pathological process in kidney operation, is always seen in extracorporeal shock wave lithotripsy and renal transplantation, and even the main reason leading to acute kidney injury. The pathogenesis of renal ischemia reperfusion injury (RIRI) is complex so that we have not found better drugs in clinical to prevent and treat it. P38 signaling pathway activation is one of the important mechanisms leading to renal ischemia reperfusion injury. This article reviewed the main functions of P38 mitogen activated protein kinases (P38MAPK) signaling pathway and its role in RIRI in order to provide a new idea for the prevention and treatment of RIRI.
Key words:
p38 mitogen-activated protein kinases/ME; Signal transduction; Reperfusion injury/ME; Kidney diseases/ME; Ischemia; Review
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