Roles of TRIB3 in unfolded protein response

Endoplasmic reticulum stress in tumor cells is common,the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum can lead to unfolded protein response (UPR).Research shows that UPR can protect cells,reestablish endoplasmic reticulum function and homeostasis at initial stage,and can promote apoptotic at later stage.TRIB3 is one of the mammal pseudoprotein kinase family Tribbles,and plays an important pivotal role in UPR,which can not only promote apoptosis but also play a protective role. Key words: Neoplasms;  Endoplasmic reticulum;  TRIB3;  Unfolded protein response