SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGP-T) IN HEPATIC DISEASE: A PRELIMINARY REPORT

Article1 November 1956SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGP-T) IN HEPATIC DISEASE: A PRELIMINARY REPORTFELIX WRÓBLEWSKI, M.D., F.A.C.P., JOHN S. LADUE, M.D., F.A.C.P.FELIX WRÓBLEWSKI, M.D., F.A.C.P., JOHN S. LADUE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-5-801 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSignificant and characteristic alterations in the activity of serum glutamic oxaloacetic (SGO-T) have been shown to follow acute heart muscle and liver cell injury and to provide a rough index of the degree of such damage.1, 2The activity of glutamic oxaloacetic transaminase (GO-T) and that of glutamic pyruvic transaminase (GP-T) in homogenates of various human tissues are compared in table 1. The relative concentration of GP-T in liver as compared with heart tissue and skeletal muscle is proportionately greater than that of GO-T. This observation suggested that serum glutamic pyruvic transaminase (SGP-T) might be a more specific index...Bibliography1. WróblewskiLaDue FJS: Serum glutamic oxaloacetic transaminase activity as an index of liver cell injury: a preliminary report, Ann. Int. Med. 43: 345-360, 1955. LinkGoogle Scholar2. LaDueWróblewski JSF: The significance of the serum glutamic oxaloacetic transaminase activity following acute myocardial infarction, Circulation 11: 871-877, 1955. CrossrefMedlineGoogle Scholar3. KarmenWróblewskiLaDue AFJS: Transaminase activity in human blood, J. Clin. Investigation 34: 126-133, 1955. CrossrefMedlineGoogle Scholar4. WróblewskiLaDue FJS: Serum glutamic pyruvic transaminase in cardiac and hepatic disease, Proc. Soc. Exper. Biol. and Med. 91: 569-571, 1956. CrossrefMedlineGoogle Scholar5. WróblewskiCabaud FP: Colorimetric measurement of serum glutamic pyruvic transaminase, in press. Google Scholar6. MolanderWróblewskiLaDue DWFJS: Serum glutamic oxaloacetic transaminase as an index of hepatocellular integrity, J. Lab. and Clin. Med. 46: 831-839, 1955. MedlineGoogle Scholar7. NydickWróblewskiLaDue IFJS: Evidence for increased serum glutamic oxaloacetic transaminase (SGO-T) activity following graded myocardial infarcts in dogs, Circulation 12: 161-168, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 17, 1956.From the Sloan-Kettering Institute and the Department of Medicine, Memorial Center, New York, N. Y.†This study was supported in part by the New York Heart Association and in part by Grant H-1978 of the National Institutes of Health.Requests for reprints should be addressed to Felix Wróblewski, M.D., 444 East Sixty-eighth Street, New York 21, N. Y. 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