Meta-analysis of the Efficacy of Baitouweng Decoction in the Treatment of Ulcerative Colitis and its Influence on Inflammatory Factors

Objective: To systematically evaluate the efficacy of Baitouweng Decoction in the treatment of ulcerative colitis (UC) and its influence on inflammatory factors.Methods: The relevant literature was retrieved by computer.The retrieval databases included China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP and CBM.The retrieval time was set to be from the establishment of the database to July 28, 2021.The included literature was analyzed by RevMan 5.3 software.Results: A total of 11 articles were included, and a total of 902 patients with ulcerative colitis were included.Meta-analysis showed that Baitouweng Decoction was superior to conventional Western medicine in the treatment of ulcerative colitis.Among them, the clinical effective rate[OR=4.24,95%CI(2.74,6.54),Z=6.52, P<0.0001] and clinical cure rate[OR=1.93,95%CI(1.03,3.62),Z=2.04,P=0.04]were higher than Western medicine treatment group.Interleukin-6 (IL-6)[MD=-38.88,95%CI(-41.30,-36.47),Z=31.65,P<0.0001], Interleukin-8 (IL-8)[MD=-10.41,95%CI(-11.58,-9.24),Z=17.45,P<0.0001] and tumor necrosis factor α (TNF-α)[MD=-11.31,95%CI(-12.02,-10.60),Z=31.18,P<0.0001] were lower than those in the Western medicine treatment group.Interleukin-10 (IL-10)[MD=6.89,95%CI(5.06,8.72),Z=7.38, P<0.0001] was higher than that in the Western medicine treatment group.Conclusion: Compared with conventional Western medicine in the treatment of ulcerative colitis, Baitouweng Decoction has better curative effect and better inhibitory effect on inflammatory factor levels.