抗体-药物偶联物
医学
单克隆抗体
药品
结合
药理学
肿瘤科
癌症研究
抗体
免疫学
数学分析
数学
出处
期刊:PubMed
[National Institutes of Health]
日期:2021-01-23
卷期号:43 (1): 78-91
被引量:3
标识
DOI:10.3760/cma.j.cn112152-20201112-00981
摘要
Antibody-drug conjugate (ADC) is a type of targeted biological agent which connect cytotoxic drug to monoclonal antibody by a connector head, which enables monoclonal antibody acted as a carrier to efficiently transport small molecular cytotoxic drugs to target tumor cells. It is very important for clinicians to have an in-depth understanding of the molecular characteristics and mechanism of ADC drugs, rationally choose the appropriate dose, course of treatment and manage adverse reactions according to the indications during the clinical application of ADC drugs, which may even affect the survival of patients. Therefore, the consensus aims to conduct a systematic overview of commercially available ADC drugs, provide effective recommendations and references for clinicians to better apply and manage ADC drugs.
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