医学
幽门螺杆菌
疾病
消化性溃疡
消化性
重症监护医学
人口
抗菌剂
幽门螺杆菌感染
内科学
胃肠病学
免疫学
环境卫生
微生物学
生物
作者
Ángel Lanas,Francis K.L. Chan
出处
期刊:The Lancet
[Elsevier]
日期:2017-08-01
卷期号:390 (10094): 613-624
被引量:534
标识
DOI:10.1016/s0140-6736(16)32404-7
摘要
The rapidly declining prevalence of Helicobacter pylori infection and widespread use of potent anti-secretory drugs means peptic ulcer disease has become substantially less prevalent than it was two decades ago. Management has, however, become more challenging than ever because of the threat of increasing antimicrobial resistance worldwide and widespread use of complex anti-thrombotic therapy in the ageing population. Peptic ulcers not associated with H pylori infection or the use of non-steroidal anti-inflammatory drugs are now also imposing substantial diagnostic and therapeutic challenges. This Seminar aims to provide a balanced overview of the latest advances in the pathogenetic mechanisms of peptic ulcers, guidelines on therapies targeting H pylori infection, approaches to treatment of peptic ulcer complications associated with anti-inflammatory analgesics and anti-thrombotic agents, and the unmet needs in terms of our knowledge and management of this increasingly challenging condition.
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