废止
化学
苯乙酮
喹啉
结合
级联
过渡金属
碳纤维
组合化学
迈克尔反应
溶剂
有机化学
催化作用
数学分析
复合材料
材料科学
复合数
色谱法
数学
作者
Sandip Balasaheb Wakade,Dipak Kumar Tiwari,Pothapragada S. K. Prabhakar Ganesh,Mandalaparthi Phanindrudu,Pravin R. Likhar,Dharmendra Kumar Tiwari
出处
期刊:Organic Letters
[American Chemical Society]
日期:2017-09-07
卷期号:19 (18): 4948-4951
被引量:95
标识
DOI:10.1021/acs.orglett.7b02429
摘要
A transition-metal-free method for the construction of functionalized quinolines from readily available acetophenones and anthranils is reported. This one-pot reaction cascade involves in situ generation of α,β-unsaturated ketones from the acetophenone via one-carbon homologation by DMSO followed by the aza-Michael addition of anthranils and subsequent annulation. DMSO acted in this reaction not only as solvent but also as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 3-substituted quinolines.
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