Clinical Study: Effect of Supplementation with High Genistein Soybean Isoflavones and Pumpkin Standardized Extract on Urinary Incontinence in Western Perimenopausal Women

Objective: To examine the effect of supplementation of a novel combination of high genistein soybean extract and pyrogallol plus polyphenols from standardized pumpkin seed extract in perimenopausal women with urinary (UI) incontinence. Methods:The present study investigated the effects of a dietary supplement formula containing high genistein soybean extract and pumpkin seed extract (DROPSORDRY™) on 82 perimenopausal women diagnosed with urinary incontinence.Subjects received 2 tablets of DROPSORDRY™ per day for 4 weeks, followed by 1 tablet per day for an additional 4 weeks.Subjects recorded UI symptoms and quality of life before supplementation for 14 days and for 8 weeks during treatment.Paired difference test (Wilcoxon test) was used to determine if there was a significant improvement in UI symptoms before and after treatment.Results: Compared to baseline data, statistically significant decreases were observedin mean urgency grade (24.7%;P<0.01), nocturia (69.35%;P<0.05) and the use of daily pantyliners (66.25%; p<0.01).In addition, in the quality of life was improved in 92.3% of the subjects. Conclusion:The results suggest that DROPSORDRY™ supplementation is a safe and an effective strategy for reducing urinary incontinence symptoms and quality of life in Western perimenopause women.