Aromatic C-H addition of ketones to imines enabled by manganese catalysis

)-H addition of ketones to imines enabled by manganese catalysis, which totally reverses the innate reactivity of C-H bonds α to the carbonyl and those on the aromatic ring. Diverse products of ortho-C-H aminoalkylated ketones, cyclized exo-olefinic isoindolines, and three-component methylated isoindolines can be successfully accessed under mild reaction conditions, which significantly expands the synthetic utilities of ketones as simple bulk chemicals.