髓鞘
生物
磷酸二酯酶
脊椎动物
细胞生物学
功能(生物学)
斑马鱼
环核苷酸
核苷酸
生物化学
基因
酶
中枢神经系统
神经科学
作者
Matti Myllykoski,Leonie Seidel,Gopinath Muruganandam,Arne Raasakka,Andrew E. Torda,Petri Kursula
标识
DOI:10.1016/j.brainres.2015.09.004
摘要
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant membrane-associated enzyme within the vertebrate myelin sheath. While the physiological function of CNPase still remains to be characterized in detail, it is known - in addition to its in vitro enzymatic activity - to interact with other proteins, small molecules, and membrane surfaces. From an evolutionary point of view, it can be deduced that CNPase is not restricted to myelin-forming cells or vertebrate tissues. Its evolution has involved gene fusion, addition of other small segments with distinct functions, such as membrane attachment, and possibly loss of function at the polynucleotide kinase-like domain. Currently, it is unclear whether the enzymatic function of the conserved phosphodiesterase domain in vertebrate myelin has a physiological role, or if CNPase could actually function - like many other classical myelin proteins - in a more structural role. This article is part of a Special Issue entitled SI: Myelin Evolution.
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