Effects of combination of sodium glycididazole with cisplatin on sensitivity of cervical carcinoma cell line HeLa

Objective Sodium glycididazole(CMNa) was a novel tumor radiosensitizer,used on radiosensitizing research of laryngeal carcinoma, pharyngeal cancer, and lung cancer. It had obtained remarkable effection. The effects of CMNa on chemotherapy was still not affirmed. This research took the cervical adenocarcinoma HeLa cells as target cells, analyzed whether CMNa effected the chemosensitivity of cisplatin on cervical adenocarcinoma HeLa cells. Methods HeLa cells were subjected to cisplatin(DDP), CMNa, and both of them in various concentrations for 24 hours, and the morphology of the HeLa cells was observed. MTT colorimetry was used to determine the effects of the drugs on HeLa cells. Results The HeLa cells treated with different concentrations of cisplatin underwent cell proliferation inhibition. Various concentrations of CMNa were not effected the HeLa cells. CMNa could strengthen the effects of low-concentrated DDP on HeLa cells greatly. Conclusion The combination of CMNa and DDP could not only enhance the sensitivity of DDP to HeLa cells, but also decrease the dosage of DDP,which could provide theoretical guidance for cervical carcinoma.