Research on pollution and health risk by antibiotics in source water of Shiyan Reservoir in Shenzhen

Objective To explore the pollution and the potential health hazards of ten selected antibiotics in source water of Shiyan Reservoir in Shenzhen,Guangdong province,China.Methods The concentrations of antibiotics(amoxicillin,metronidazole,cefalexin,lincomycin,sulfadimidine,sulfamethoxazole,erythromycin-H2 O,roxithromycin,cefuroxime,chloromycetin) in water source from six points were determined in September,2012 and January,2013 in Shiyan Reservoir,by solid-phase extraction,high performance liquid chromatography and tandem mass spectrometry.Monte Carlo method was applied to assess the health risk of antibiotics pollution in the source water.Results Eight kinds of antibiotics including metronidazole,cefalexin,lincomycin,sulfadimidine,sulfamethoxazole,erythromycin-H2 O,roxithromycin,cefuroxime were detected in Shiyan Reservoir,with the concentrations ranged from 1.1 to 68 ng/L.The concentrations of lincomycin,erythromycin-H2 O,sulfadimidine and sulfamethoxazole were relatively higher than others,while amoxicillin and chloromycetin were not detected in six sampling points.The antibiotic contamination levels in dry season were higher than in wet season,and in Shiyan River were much higher than in the reservoir and external diversion.The total health risk of 10 antibiotics were in range of 5.55 ×10-6~5.30×10-4,which were much less than 1,the health risks came mostly from lincomycin and erythromycin-H2 O.The health risk for the adults were lower than that for the children caused by antibiotics except cefuroxime.Conclusion It can be considered that antibiotics in the source water of Shiyan Reservoir in Shenzhen won't cause obvious health hazard to human beings currently.