Endoplasmic reticulum stress and alcoholic liver disease

Endoplasmic reticulum stress as a new concern during the pathogenesis of alcoholic liver disease(ALD)has entered the people's vision.Endoplasmic reticulum stress caused by the accumulation of misfolded and unfolded proteins in the endoplasmic reticulum.Appropriate stress was benefical to recovery of intracellular environment,however,serious and persistent stress may lead to apoptosis.Hepatocytes are one of the most sensitive cells,which contain abundant endoplasmic reticulum.Existing study has indicated that endoplasmic reticulum contributed to the development of ALD in cell and animal models.In this review,we summaried the role of endoplasmic stress in the pathogenesis of ALD.