Progress on Construction and Research of Sensing Films of Molecularly Imprinted Electrochemical Sensors

Molecular imprinting technique(MIT) has been widely applied in chromatographic separation,solid phase extraction,biomimetic sensor,enzymatic catalysis and membrane separation,etc.In recent years,molecularly imprinted electrochemical sensors(MIECS) have been received more and more attentions.Combining with characteristic of electrochemical technique and MIT,MIECS offered significantly lower detection limit and low cost with the possibility of easy miniaturization.For the MIECS,molecularly imprinted sensing film must combine with transducer effectively in order to recognize and analyze the targe molecules.So construction of appropriate molecularly imprinted sensing film system is very important for the design of MIECS.In this paper,detection principle and classification of MIECS have been introduced.The construction methods and characteristic of five kinds of sensing film systems,including traditional system,self-assembly system,molecularly imprinted polymer particles embedded system,electro-polymerized system and sol-gel system,were introduced,and theri application were summarized.The prospects development of MIECS was viewed.