The New Breakthrough of Transplantation Immunology and Organ Transplantation

Transplantation immunology is the basis of modern organ transplantation.The history of organ transplantation demonstrated that the progress of basic research of transplantation immunology played critical role in the success of clinical organ transplantation.Based on the discovery of microchimerism of long-surviving organ recipients,Early of 1990's Starzl proposed his “Two-way paradigm” of graft rejection,reflecting the rule and characters of the graft rejection in the condition of immunosuppress-based clinical organ transplantation.The proposal of Two-way paradigm is an important theoretical progress in the history of transplantation immunology,which will greatly impulse the advance on the induction of transplantation tolerance in clinic.