THE DIFFERENCES IN SOME LNDEXES OF CALCIUM HOMEOSTASIS BETWEEN THE TWO TYPES OF ASCITES HEPATOMA CELL LINE

In this paper,Hca-F25/CL-16A3 and Hca-F25/CL-A2 with high and low metastatic ability respectively were used. Some indexes of intracellular calcium homeostasis were determined. The results showed that cytosolic free Ca2+ concentration level of mitochondrial calcium and activity of microsomel Ca2+-ATPase of 16A3 were obviously higher than those in A2. While the level of total calcium and nucleus calcium in 16A3 were lower than those in A2. The results indicated that there were significant differences in calcium homeostasis between the two cell clones with different matastatic abilities via lymph tract, and also suggested that the calcium homeostasis. was closely associated with the metastasis of tumor cells.