Homing regularity of different doses bone marrow transplantation in allogeneic hosts

Objective To explore the homing regularity of different doses of bone marrow cell transplantation.Method An allogeneic mouse model was used in this study.The homing status of different dose groups from the first day to the forth day after transplantation were observed.Results The rate of positive cells in bone marrow and spleen:differences among four groups was not significant.The rate of positive cells of third day was highest among four days ( P 0 01).A phenomenon that homing\|mobilization\|rehoming could be observed.The homing efficiency:low dose groups were higher than that high dose groups ( P 0.01).Conclusion The homing efficiency of low dose groups is higher than that of the high dose groups in certain range,the routine method of transplanting a large quantities cells by a single injection may be an waste.