胆红素
医学
氧化应激
癌症
分解代谢
发病机制
血红素
内科学
免疫学
生理学
生物
生物化学
新陈代谢
酶
出处
期刊:PubMed
日期:2016-04-19
卷期号:155 (2): 10-4
被引量:4
摘要
Oxidative stress contributes importantly to pathogenesis of numerous civilization diseases, including cardiovascular diseases, cancer, as well as autoimmune and neurodegenerative conditions. Bilirubin is the major product of the heme catabolic pathway in the intravascular compartment. For long time, bilirubin was considered to be only a waste product, however, recent data from the last two decades have proved its important protective properties, which contributes to defense against development of civilization diseases. Numerous experimental as well as clinical studies have demonstrated association between low bilirubin concentrations and cardiovascular diseases, as well as certain cancers. On the other hand, subjects with mildly elevated blood bilirubin levels, typical for Gilbert syndrome, have decreased risk of these diseases.
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