Association of PTX3 in GCF with Chronic Periodontitis

Objective:To study the changes of Pentraxin-3(PTX3)levels in gingival crevicular fluid(GCF)of chronic periodintitis(CP)pre-and after-periodontal treatment and the relationship between them and periodontal indexe and to explore the relationship between the PTX3levels and periodontal status.Methods:GCF samples were obtained from 20healthy teeth and 20diseased teeth of 20periodontal patients before and at 4weeks after the periodontal therapy.At the same time,probing depth(PD),clinical attachment loss(CAL),sulcus bleeding index(SBI)were evaluated pre-and after-therapy.The concentration of PTX3were detected by enzymelinked immunosorbent assay(ELISA).Results:The level of PTX3in GCF in inflammation group was significantly higher than health group.After periodontal treatment,the level of PTX3in GCF of CP were down–regulated.Furthermore,the level of PTX3showed statistical positive correlations with PD,SBI and CAL(P0.01,P0.01,P0.05).Conclusion:The level of PTX3in GCF may show significant correlations with periodontal tissue inflammation.