Adsorption experiments were undertaken to study the decolorization effect of seven macroporous resins and three ion exchange resins on Silybum marianum polysaccharides, and D900 anion exchange resin was selected as the decolorizing resin. The optimum decolorization condition was determined by single factor test and orthogonal experiment according to temperature, p H value, solution concentration, and dynamic adsorption experiments were carried out. The results showed that under the conditions of using D900 resin, temperature of 50 ℃, p H value of 5, solution concentration of 3 mg/m L, column speed of 1 m L/min, column capacity of 1.5 BV, the decolorization rate of Silybum marianum polysaccharides was 80.23%, and the retention rate of the polysaccharides was 85.56%.