Influence of Huangzhu Dingxian Capsules on Epileptic Seizure of Epilepsy Model Rats

Objective:To study the influence of Huangzhu Dingxian capsules on epileptic seizure of amyl tetrazolium(PTZ)-induced epilepsy rats,and to discuss its antiepileptic mechanism.Methods:The high-dose group was given Huangzhu Dingxian capsules 6 mL,3 times/day,and the small-dose group given Huangzhu Dingxian capsules 2 mL,3 times/day,continuously for 28 d.Valproic acid sodium group was given valproic acid sodium 400 mg/kg,3 times/day,continuously for 28 d.Normal control group and model control group were given physiological saline,3 times/d,1 mL/time,continuously for 28 d.The body weight,seizure level and duration of change were observed.Results:The weight gain and seizure level were reduced,and the attack last time was shortened.It showed that Huangzhu Dingxian capsules had good resistance to epilepsy action.The high-dose group and the small-dose group had significant differences in antiepileptic effect and dose-dependent manner.Conclusion:Huangzhu Dingxian capsules could significantly inhibit PTZ-induced epilepsy.