A Preliminary Study on Apoptosis and the Tumor Related Genes of Colorectal Adenoma

Objective To search the colorectal adenoma related genes. Methods Differentially expressed genes of colorectal adenoma tissues and colorectal mucous membranes were identified by microarray-based detection. Part of differentially expressed genes were identified by semiquantitative RT-PCR. Results Among them,85 were leveled up.197 were leveled down.Conclusion In a general,comparison with normal colorectal mucous membranes,282 different expression genes were found in colorectal adenoma. Apoptosis and carcinoma related gene may play an important role in pathogenesis of colorectal adenoma.