伤口愈合
葡萄糖氧化酶
化学
葡萄糖酸
谷胱甘肽
催化作用
氧化应激
抗菌活性
药理学
组合化学
癌症研究
细菌
生物化学
医学
外科
酶
生物
遗传学
作者
Xiang Wang,Cheng Ding,Ziwen Zhang,Chunlin Li,Dongmiao Cao,Linjing Zhao,Guoying Deng,Yu Luo,Chunping Yuan,Jie Lü,Xijian Liu
标识
DOI:10.1016/j.cclet.2022.107951
摘要
Diabetic patients often have problems such as residual tumor and wound infection after tumor resection, causing severe clinical problems. It is urgent to develop effective therapies to reach oncotherapy/anti-infection/promotion of wound healing combined treatment. Herein, we propose CS/MnO2-GOx (CMGOx) nanocatalysts for the specific catalytic generation of •OH to inhibit tumors and bacteria in a hyperglycemic environment. The good biocompatible chitosan (CS), as a carrier for the catalyst, exhibits excellent antibacterial effect as well as promotes wound healing. Glucose oxidase (GOx) is loaded on the surface of CS nanoparticles to generate H2O2 and gluconic acid by consuming glucose (starvation therapy, ST) and O2. The MnO2 depletes glutathione (GSH) to produce Mn2+, amplifying oxidative stress and further promoting the activity of Mn2+-mediated Fenton-like reaction to produce •OH (chemodynamic therapy, CDT) in weak acidic environment. Moreover, the produced gluconic acid lowers the pH of the environment, enhancing chemodynamic therapy (ECDT). The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT. The MnO2 nanoparticles at neutral environment decomposes H2O2 into O2, which cooperate with CS to promote healing. The self-enhanced cascade reaction of CMGOx in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing, offering a promising integrated treatment for diabetic patients after tumor surgical resection.
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