Spin and Gradient Multiple Overlapping‐Echo Detachment Imaging ( SAGE ‐ MOLED ): Highly Efficient T 2 , T2*$$ {T}_2^{\ast } $$, and M 0 Mapping for Simultaneous Perfusion and Permeability Measurements

PURPOSE: mapping for perfusion MRI. METHODS: -related effects, providing training data for an end-to-end deep learning model that enables efficient multiparametric quantification. In addition, a signal-to-concentration model tailored for dynamic MOLED signals was formulated for accurate estimation of permeability and leakage-corrected perfusion parameters. The proposed technique was validated in water phantom experiments, healthy volunteers, and a pilot clinical study. RESULTS: mapping in the brain. Compared to conventional SAGE-EPI, SAGE-MOLED mitigated geometric distortions and intravoxel dephasing-related signal loss. In perfusion MRI, dynamic SAGE-MOLED enabled simultaneous permeability and leakage-corrected perfusion parameter estimation with a single-dose contrast injection. CONCLUSION: maps for simultaneous quantification of permeability and perfusion parameters.