嵌合抗原受体
细胞疗法
免疫疗法
癌症研究
淋巴因子激活杀伤细胞
生物
免疫学
自杀基因
肾细胞癌
移植
遗传增强
T细胞
细胞
医学
免疫系统
肿瘤科
白细胞介素21
内科学
遗传学
生物化学
基因
作者
Yufei Wang,Eloah Rabello Suarez,Gabriella Kastrunes,Najla Santos Pacheco de Campos,Rabia J. Abbas,Renata Schmieder Pivetta,Nithyassree Murugan,Ghanbar Mahmoodi Chalbatani,Vincent D’Andrea,Wayne A. Marasco
标识
DOI:10.1186/s12943-023-01911-x
摘要
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with surgical resection of tumors to targeted therapy, immunotherapy, and combination therapies. However, curative treatment, particularly for advanced-stage disease, remains rare. Cell therapy as a "living drug" has achieved hematological malignancy cures with a high response rate, and significant research efforts have been made to facilitate its translation to solid tumors. Herein, we overview the cellular therapies for RCC focusing on allogeneic hematopoietic stem cell transplantation, T cell receptor gene-modified T cells, chimeric antigen receptor (CAR) T cells, CAR natural killer (NK) cells, lymphokine-activated killer (LAK) cells, γδ T cells, and dendritic cell vaccination. We have also included perspectives for using other recent approaches, such as CAR macrophages, dendritic cell-cytokine induced killer cells and regulatory CAR-T cells to shed light on preclinical development of cell therapy and advancing cell therapy into clinic to achieve cures for RCC.
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