戒指(化学)
苯胺
催化作用
镍
化学
组合化学
配体(生物化学)
锰
药物化学
立体化学
有机化学
受体
生物化学
作者
Karunanithi Rajamanickam,Sunwoo Lee
标识
DOI:10.1021/acs.joc.3c02486
摘要
We successfully developed a nickel-catalyzed transamidation method for the ring opening of N-acyl lactams. The method involves a reaction between N-benzoylpyrrolidin-2-one derivatives and aniline derivatives, with Ni(PPh3)2Cl2 serving as the catalyst, 2,2′-bipyridine as the ligand, and manganese as the reducing agent. This reaction led to the formation of ring-opening-amidated products in good yields. Notably, the method exhibited excellent efficiency for producing the corresponding ring-opening transamidation products for various ring sizes, including four-, five-, six-, seven-, and eight-membered ring lactams.
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