结肠炎
食品科学
肠道菌群
发酵
麸皮
炎症性肠病
化学
毛螺菌科
丁酸
功能性食品
生物
生物化学
溃疡性结肠炎
微生物学
免疫学
医学
厚壁菌
内科学
原材料
有机化学
疾病
基因
16S核糖体RNA
作者
Hua Wang,Menglin Li,Fu-Rong Jiao,Wenwei Ge,Rui Li,Zijian Zhi,Tao Wu,Wenjie Sui,Min Zhang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2024-01-01
卷期号:15 (2): 516-529
摘要
Ulcerative colitis is a chronic inflammatory disease with a complex pathogenesis for which there is no definitive therapeutic agent. Fermentation, as a green and efficient bioprocessing technique, has been shown to enhance the biological activity of food ingredients. Soluble dietary fiber isolated from plants is thought to have the potential to prevent and alleviate ulcerative colitis. This work was designed to study the differences in the chemical properties of the soluble dietary fiber from wheat bran fermented by Isaria cicadae Miq. (FSDF) and the unfermented soluble dietary fiber from wheat bran (UFSDF) and their effects on colitis mice. The results showed that FSDF and UFSDF differed in molecular weight, monosaccharide compositions, and surface morphology. In addition, supplementation with UFSDF and FSDF ameliorated the symptoms of DSS-induced colitis in mice by attenuating body weight loss, decreasing the disease activity index and splenic index, shortening the length of the colon, and attenuating colonic tissue damage. UFSDF and FSDF also increased the production of the anti-inflammatory cytokine IL-10 and inhibited the expression of IL-6, IL-1β, and TNF-α. The results of gut flora and short-chain fatty acid analyses showed that UFSDF and FSDF improved the diversity of gut microbiota, up-regulated the abundance of some beneficial bacteria such as Akkermansia and Muribaculaceae, increased the levels of acetic acid, propionic acid, and butyric acid, and restored dextran sodium sulfate (DSS)-induced dysbiosis of the intestinal flora in mice. These findings provide guidance for the development of FSDF and UFSDF as functional foods for the relief of ulcerative colitis.
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