氰化
化学
碱基
核苷
组合化学
钯
芳基
催化作用
酰胺
立体化学
有机化学
生物化学
DNA
烷基
作者
Anant R. Kapdi,Yogesh S. Sanghvi,Harshita Shet,Rajesh Sahu
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-04-24
卷期号:35 (06): 654-658
被引量:1
摘要
Abstract Installation of cyano group functionality onto nucleosides has always been a challenging task for chemists, and catalytic protocols developed for simple aryl substrates have, in most cases, failed to replicate their success when applied to nucleobase or sugar moieties of nucleosides. Given the importance of the cyano and amide functionalities in nucleoside chemistry, we herein disclose an efficient Pd-catalyzed cyanation protocol specifically applied to iodo nucleobases. Furthermore, the developed cyanation method has been explored for the synthesis of naturally occurring and bioactive nucleosides such as toyocamycin, sangivamycin, and a mycalisine A precursor.
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