夜行的
节奏
昼夜节律
转录组
能量平衡
平衡(能力)
生物
能量(信号处理)
神经科学
生态学
内科学
医学
物理
遗传学
基因表达
基因
量子力学
作者
Laura van Rosmalen,Shaunak Deota,Geraldine Maier,Hiep D. Le,Terry Lin,Ramesh Ramasamy,Roelof A. Hut,Satchidananda Panda
出处
期刊:Cell Reports
[Elsevier]
日期:2024-03-01
卷期号:: 113951-113951
标识
DOI:10.1016/j.celrep.2024.113951
摘要
Summary
Plasticity in daily timing of activity has been observed in many species, yet the underlying mechanisms driving nocturnality and diurnality are unknown. By regulating how much wheel-running activity will be rewarded with a food pellet, we can manipulate energy balance and switch mice to be nocturnal or diurnal. Here, we present the rhythmic transcriptome of 21 tissues, including 17 brain regions, sampled every 4 h over a 24-h period from nocturnal and diurnal male CBA/CaJ mice. Rhythmic gene expression across tissues comprised different sets of genes with minimal overlap between nocturnal and diurnal mice. We show that non-clock genes in the suprachiasmatic nucleus (SCN) change, and the habenula was most affected. Our results indicate that adaptive flexibility in daily timing of behavior is supported by gene expression dynamics in many tissues and brain regions, especially in the habenula, which suggests a crucial role for the observed nocturnal-diurnal switch.
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