孟德尔随机化
混淆
医学
乳腺癌
2型糖尿病
因果关系(物理学)
观察研究
肿瘤科
因果推理
遗传关联
癌症
内科学
糖尿病
遗传学
单核苷酸多态性
基因
基因型
内分泌学
生物
遗传变异
病理
物理
量子力学
作者
Lihan Zhang,Shuochuan Liu,Guangxing Yue,Hong Niu,Mengjin Hu,Yan Zheng,Jingwen Tang
出处
期刊:Future Oncology
[Future Medicine]
日期:2024-04-19
标识
DOI:10.2217/fon-2023-0708
摘要
Objective: Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and vice versa. However, it is uncertain whether the link is causal or just due to confounding factors. Using bidirectional Mendelian randomization analysis, we assessed the bidirectional causal relationship from a genetic level. Methods: Large genome-wide association studies yielded summary-level data for Type 2 diabetes and breast cancer. Results: Genetically predicted Type 2 diabetes presented no statistically significant association with overall breast cancer or its subtypes. Similarly, genetically predicted overall breast cancer or its subtypes had no causal effect on Type 2 diabetes. Sensitivity analyses yielded similar results. Conclusion: Our bidirectional Mendelian randomization studies revealed no causal links between Type 2 diabetes and breast cancer.
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