造血
生物
干细胞
祖细胞
血小板
细胞生物学
谱系(遗传)
祖细胞
骨髓
巨核细胞
免疫学
遗传学
基因
作者
Bryce Manso,Alessandra Rodriguez y Baena,E. Camilla Forsberg
出处
期刊:Cells
[MDPI AG]
日期:2024-04-19
卷期号:13 (8): 704-704
被引量:8
标识
DOI:10.3390/cells13080704
摘要
Platelets are the terminal progeny of megakaryocytes, primarily produced in the bone marrow, and play critical roles in blood homeostasis, clotting, and wound healing. Traditionally, megakaryocytes and platelets are thought to arise from multipotent hematopoietic stem cells (HSCs) via multiple discrete progenitor populations with successive, lineage-restricting differentiation steps. However, this view has recently been challenged by studies suggesting that (1) some HSC clones are biased and/or restricted to the platelet lineage, (2) not all platelet generation follows the “canonical” megakaryocytic differentiation path of hematopoiesis, and (3) platelet output is the default program of steady-state hematopoiesis. Here, we specifically investigate the evidence that in vivo lineage tracing studies provide for the route(s) of platelet generation and investigate the involvement of various intermediate progenitor cell populations. We further identify the challenges that need to be overcome that are required to determine the presence, role, and kinetics of these possible alternate pathways.
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