光热治疗
生物膜
激进的
化学
螯合作用
烷基
灭菌(经济)
抗菌剂
光热效应
材料科学
组合化学
化学工程
纳米技术
细菌
有机化学
遗传学
工程类
生物
货币经济学
经济
外汇市场
外汇
作者
Wen Liu,Bao‐Lian Su,Hua Song,Xueyun Zhang,Guodong Ren,Xuewei Wang,Lili Yan,Sufang Ma,Lihong Li,Lixia Guo,Shuming Xu,Boye Zhang,Hongwei Diao,Zhiyong Wu,Sijin Li,Chengwu Zhang
标识
DOI:10.1016/j.arabjc.2024.105755
摘要
Staphylococcus aureus has become one of the most common pathogens in clinical tissue infection, and it is easy to form biofilm. Incomplete removal of biofilms often leads to recurrent infections, and more serious is the possibility of bacteria developing drug resistance. Therefore, the effective eradication of refractory biofilms is essential. Herein, a temperature-sensitive hydrogel was prepared by doping the photothermal carbon dots (PTCDs) chelated by Ag+, and the AIPH which can produce alkyl radicals in response to heat into the thermodissolved gelatin. Under the irradiation of 660 nm laser, the PTCDs generate heat to dissolve the hydrogel, and prompting chelation of silver ions in PTCDs for chemical sterilization. Meanwhile, the heat generated by the PTCDs induce the 2,2′-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) to produce alkyl free radical sterilization, achieving the purpose of photothermal/thermodynamic/chemical synergistic to kill Staphylococci aureus and destroy its biofilm. Therefore, the biocompatible PTCDs@Ag-AIPH hydrogel proposed in this study is a promising composite that can eliminate biofilms and promote wound healing, showing good potential in future biomedical applications.
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