Older adults with cancer and common comorbidities—challenges and opportunities in improving their cancer treatment outcomes

癌症 医学 老年肿瘤学 人口 临床试验 共病 癌症幸存者 生存曲线 耐受性 老年学 替代医学 内科学 病理 环境卫生
作者
Weiwei Chen,Rachel D. Altshuler,Phil Daschner,Carolina Salvador-Morales,Diane St. Germain,Jennifer Guida,Pataje G.S. Prasanna,Jeffrey C Buchsbaum
出处
期刊:Journal of the National Cancer Institute [Oxford University Press]
卷期号:116 (11): 1730-1738 被引量:4
标识
DOI:10.1093/jnci/djae163
摘要

Abstract The older American population is rapidly increasing, and millions of older adults will be cancer survivors with comorbidities. This population faces specific challenges regarding treatment and has unique clinical needs. Recognizing this need, the National Cancer Institute, in collaboration with the National Institute on Aging, hosted a webinar series, entitled Cancer, Aging, and Comorbidities. This commentary provides a reflection of 5 thematic areas covered by the webinar series, which was focused on improving cancer treatment for older adults with cancer and comorbidities: 1) the impact of comorbidities on treatment tolerability and patient outcomes; 2) the impact of comorbidities on cancer clinical trial design; 3) the development of wearable devices in measuring comorbidities in cancer treatment; 4) the effects of nutrition and the microbiome on cancer therapy; and 5) the role of senescence and senotherapy in age-related diseases. Advances have been made in these areas, however, many gaps and challenges exist and are discussed in this commentary. To improve cancer survivorship in older populations with comorbidities, aging and comorbidities must be jointly considered and incorporated across the spectrum of cancer research. This includes more basic research of the mechanisms linking comorbidities and cancer development and treatment response, building critical resources and infrastructure (eg, preclinical models and patient samples), conducting clinical trials focused on the older population, integrating geriatric assessment into cancer treatment, and incorporating novel technologies, such as wearable devices, into clinical trials and cancer care.

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