Inclusion complexation between baicalein and β-cyclodextrin and the influence of β-cyclodextrin on the binding of baicalein with DNA: a spectroscopic approach

Yousuf Sameenaa, Sowrirajan Chandrasekarana & Enoch Israel V.M.V.a*a Department of Chemistry, School of Science and Humanities, Karunya University, Coimbatore, Tamil Nadu 641 114, India* Corresponding author. Email: israelenoch@karunya.eduCommunicated by Ramaswamy H. SarmaThis work deals with the commonly studied cyclic oligosaccharide and gains importance as it is entered on a drug delivering carbohydrate and provides insight into the oligosaccharide complex–biomolecular interaction. The binding of a flavone, baicalein, to β-cyclodextrin and calf thymus DNA is studied. The binding of baicalein to calf thymus DNA in the presence of β-cyclodextrin is analysed using the UV–vis absorption and fluorescence spectroscopy. The mode of binding and structure of the baicalein–β-cyclodextrin complex are reported. The role of the structure and the stoichiometry of the inclusion complex of baicalein–β-cyclodextrin in its influence on DNA binding are analysed.Highlights• This paper deals with the binding of a flavone, baicalein to β-cyclodextrin and/or DNA.• The inclusion complexation between baicalein and β-cyclodextrin is analysed.• The stoichiometry and the binding strength of the inclusion complex is reported.• The role of β-cyclodextrin in tuning the binding of baicalein to DNA is emphasized.• Spectroscopic and docking analysis are used to articulate the results.Graphical abstractThe influence of β-cyclodextrin on the binding of baicalein with DNA