A single blind comparative study between Itraconazole and Fluconazole in the one-day treatment of vulvo-vaginal candidiasis.

This single-blind comparative study compares the efficacy and safety of oral itraconazole and fluconazole in the 1-day treatment of vulvo-vaginal candidosis. A total of 27 nonpregnant, symptomatic patients with microscopically proven vaginal candidiasis were included in the study. Patients assigned to the fluconazole group received a single oral dose of 150 mg, while those assigned to the itracozanole group received 200 mg twice a day, after breakfast and after dinner. In the analysis of comparative mycological effectiveness of the drugs, fluconazole shows a 55.6% cure rate, 33.3% failure rate, and 11% relapse/reinfection, while itraconazole has a 76.9% cure rate, 73.1% failure rate, and no relapse/reinfection. Researchers could not draw any conclusions regarding the efficacy of the two drugs because of the small sample size. However, it was found that neither drug showed any significant adverse effect. Both appear to be safe, convenient, and well tolerated at the recommended doses.