COMPARATIVE STUDY OF DORZOLAMIDE AND LATANOPROST ON INTRAOCULAR PRESSURE REDUCTION ON RABBIT’S EYE

Anti glaucoma agents are used for reduction of intraocula r pressure. The present work was carried out to compare effect of dorzolamide and latanoprost on intraocular pressure of rabbit’s eye . The study was carried out for the production of glaucoma by water loading method on rabbit’s model. In present work done by me, Anti glaucoma effect of drugs namely dorzolamide and latanoprost was c ompared with the control and with each other. Analysis of variance and student’s t - test were applied to compare the result . It was found that intraocular pressure varied significa ntly across the three groups (p = .000). Compared to control group, intraocular pressure was significantly less in both latanoprost and dorzolamide groups (p = .000). Red uction of intraocular pressure with dorzolamide was less in comparison to that of lata noprost (p = .018) at the end of work. Latanoprost is more efficacious than dorzolamide as far as intraocular pressure reduction is concerned.