Eupatorium odoratum Linn is found all over tropical Asia, western Afri ca and in parts of Australia. It is also found in Koraput district and extensively used trad itionally by the tribal people as anti-inflammatory , analgesic, antiprotozoal agent’s e.t.c. Extraction of the leaves of the plant Eupatorium Odoratum using different solvents like petroleum ether, chloroform , ethanol and their analgesic activity studies has been envisage in this present research work. All the dif ferent extracts such as petroleum ether extract, ch loroform extract and ethanolic extract has been subjected to analgesic activity studies. It has been found that only ethanolic extract (P<0.01) shows maximum analgesic activity at a dose of 300 mg/kg whereas petroleum ether extract and chloroform extract shows moderate activity at the same dose when compared with the standard drug aspirin.