自愈水凝胶
细胞外基质
组织工程
纳米技术
材料科学
DNA
生物物理学
化学
细胞生物学
生物医学工程
生物
生物化学
高分子化学
工程类
作者
Yuhan Wei,Kaizhe Wang,Shihua Luo,Liangqian Fan,Xiaolei Zuo,Chunhai Fan,Qian Li
出处
期刊:Small
[Wiley]
日期:2022-02-04
卷期号:18 (36)
被引量:38
标识
DOI:10.1002/smll.202107640
摘要
The cell microenvironment plays a crucial role in regulating cell behavior and fate in physiological and pathological processes. As the fundamental component of the cell microenvironment, extracellular matrix (ECM) typically possesses complex ordered structures and provides essential physical and chemical cues to the cells. Hydrogels have attracted much attention in recapitulating the ECM. Compared to natural and synthetic polymer hydrogels, DNA hydrogels have unique programmable capability, which endows the material precise structural customization and tunable properties. This review focuses on recent advances in programmable DNA hydrogels as artificial extracellular matrix, particularly the pure DNA hydrogels. It introduces the classification, design, and assembly of DNA hydrogels, and then summarizes the state-of-the-art achievements in cell encapsulation, cell culture, and tissue engineering with DNA hydrogels. Ultimately, the challenges and prospects for cellular applications of DNA hydrogels are delivered.
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