The Evaluation of Curcumin Self-microemulsifying Delivery System in vivo and in vitro

Objective To prepare the curcumin self-microemulsifying delivery system and to evaluate the quality in vivo and in vitro.Methods The pH,self-emulsification time,particle size,morphology,stability and dissolution of the resultant emulsion after self-emulsifying were determined.The plasma concentrations were determined by HPLC and the pharmacokinetics behavior of curcumin microemulsion was evaluated by comparison with suspension.Results The curcumin self-microemulsifying delivery system can emulsified completely within 4 min.Mean particle size of the resultant emulsion was 31.98 nm,and pH approximated to neutral.The dissolution of curcumin self-microemulsifying formulation at 10 min was 100% and the content of drug maintained above 94% with 8 h.Compared with suspension,the area under time-concentration curve(AUC) of micro-emulsion after gavage increased 12-fold.Conclusion The self-microemulsifying delivery system can significantly increase curcumin dissolution in vitro and bioavailability in vivo.