To study the influence of Herba Patriniae on lipid metabolism of rats,SD rats(male and female in half and half) were used as experimental animals.The experimental model was established with high-fat feed.Blood from eyeball was drawn after fed for 4 weeks.The contents of cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were 3.01,1.36,0.32 and 1.07,respectively.Results showed that,compared with the positive control group,the contents of TC,TG,LDL-c of the other three groups were much lower and HDL-c was significantly higher.There were remarkable differences among the different dose groups.It was concluded that Herba patriniae has action of regulating blood lipids.The Herba patriniae can be used as a functional food to be developed.