普罗帕酮
分析物
美西律
色谱法
胺碘酮
弗莱卡奈德
质谱法
化学
治疗药物监测
电喷雾
液相色谱-质谱法
决奈达隆
药代动力学
药理学
医学
内科学
心房颤动
作者
Matthew H. Slawson,Kamisha L. Johnson-Davis
出处
期刊:Methods in molecular biology
日期:2016-01-01
卷期号:: 11-19
被引量:3
标识
DOI:10.1007/978-1-4939-3252-8_2
摘要
Flecainide, mexiletine, propafenone, and amiodarone are antiarrhythmic drugs that are used primarily in the treatment of cardiac arrhythmias. The monitoring of the use of these drugs has applications in therapeutic drug monitoring and overdose situations. LC-MS/MS is used to analyze plasma/serum extracts with loxapine as the internal standard to ensure accurate quantitation and control for any potential matrix effects. Positive ion electrospray is used to introduce the analytes into the mass spectrometer. Selected reaction monitoring of two product ions for each analyte allows for the calculation of ion ratios which ensures correct identification of each analyte, while a matrix matched calibration curve is used for quantitation.
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