Absorption and isolation of macroporous resin for five salvianolic acids from Salviae mitiorrhizae

Objective To study the adsorption of the macroporous resin for the five salvianolic acids (danshen su, rosmarinic acid, protocate chualdehyde, salvianolic acid B, salvianolic acid A, extracted from Salviae mitiorrhizae. Method The five salvianolic acids were employed as an index, and the change of them in the static and dynamic absorbent was detected by HPLC, respectively. Result HP20 resin was a suitable marcoporous resin to purify salvianolic acids. The dynamic adsorption capacity of rosmarinic acid, salvianolic acid B and salvianolic acid A was 30.506 mg x g(-1) (dry resin), 36.996 mg x g(-1), (dry resin), 43.85 mg x g(-1) (dry resin) respectively. Conclusion It is not suitable that danshensu and protocate chualdehyde are the evaluation indexes for using 8 macroporous resins to purify salvianolic acids.