Development of an up-flow reactor(UFR) technique for hydrodesulfurization(HDS) of residue was described, with sulfur removal rate increment by 5.8% compared with that in fixed bed reactor under the same operation condition, or the same desulfurization rate with LHSV 50% higher than that in fixed bed reactor. Higher reaction temperature favored HDS and demetalation activity and metals were easier to be removed at the same temperature.