A synthetic peptide enhances the endotoxin-neutralizing capability of polymyxin B

AIM:To verify the role of a synthetic peptide in neutralizing endotoxins.METHODS:By model of LPS-induced TNF-α secretion in human THP-1 cells, the affects of anti-endotoxin capability of the peptide, polymyxin B, and the peptide plus polymyxin B were examined.RESULTS:Polymyxin B suppressed LPS-induced TNF-α secretion in human THP-1 cells. The peptide enhanced the capability of polymyxin B to suppress TNF-α secretion.CONCLUSION:The peptide could amplify the endotoxin-neutralizing capability of polymyxin B.