安慰剂
促炎细胞因子
内科学
植物乳杆菌
医学
氧化应激
免疫学
免疫系统
呼吸道感染
呼吸系统
胃肠病学
炎症
生物
病理
乳酸
遗传学
替代医学
细菌
作者
Hui-Xian Chong,Nur Asmaa’ A. Yusoff,Yan-Yan Hor,Lee-Ching Lew,Mariatti Jaafar,Sy Bing Choi,Muhamad Saiful Bahri Yusoff,Nabsiah Abdul Wahid,Mohammad Farris Iman Leong Bin Abdullah,Norashikin Zakaria,Kee-Leong Ong,Yong-Ha Park,Min‐Tze Liong
标识
DOI:10.3168/jds.2018-16103
摘要
The aims of this study were to investigate the effects of Lactobacillus plantarum DR7 isolated from bovine milk against upper respiratory tract infections (URTI) and elucidate the possible mechanisms underlying immunomodulatory properties. The DR7 strain (9 log cfu/d) was administered for 12 wk in a randomized, double-blind, and placebo-controlled human study involving 109 adults (DR7, n = 56; placebo, n = 53). Subjects were assessed for health conditions monthly via questionnaires, and blood samples were evaluated for cytokine concentrations, peroxidation and oxidative stress, and gene expression in T cells and natural killer (NK) cells. The administration of DR7 reduced the duration of nasal symptoms (mean difference 5.09 d; 95% CI: 0.42–9.75) and the frequency of URTI (mean difference 0.32; 95% CI: 0.01–0.63) after 12 and 4 wk, respectively, compared with the placebo. The DR7 treatment suppressed plasma proinflammatory cytokines (IFN-γ, TNF-α) in middle-aged adults (30 to 60 yr old), while enhancing anti-inflammatory cytokines (IL-4, IL-10) in young adults (<30 yr old), accompanied by reduced plasma peroxidation and oxidative stress levels compared with the placebo. Young adults who received DR7 showed higher expression of plasma CD44 and CD117 by 4.50- and 2.22-fold, respectively, compared with the placebo. Meanwhile, middle-aged adults showed lower expression of plasma CD4 and CD8 by 11.26- and 1.80-fold, respectively, compared with the placebo, indicating less T-cell activation. In contrast, both young and middle-aged adults who received DR7 showed enhanced presence of nonresting and mature NK cells compared with those who received the placebo. We postulate that DR7 alleviated the symptoms of URTI by improving inflammatory parameters and enhancing immunomodulatory properties.
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