Exploring Structural and Functional Brain Changes in Mild Cognitive Impairment: A Whole Brain ALE Meta-Analysis for Multimodal MRI

Background: Unraveling novel biomarkers for mild cognitive impairment (MCI) was highlighted in the prevention and modification of Alzheimer's disease (AD). Inconsistent results for comparison between MCI patients and healthy controls (HC) were obtained from previous neuroimaging studies. Methods: An activation likelihood estimation (ALE) meta-analysis was made for multimodal neuroimaging in MCI. After initial research and step-by-step exclusions procedures, n = 101 articles (MCI, n = 2681; HC, n = 2941, respectively) were included in the study. Results: It detected MCI related gray matter atrophy in the bilateral medial temporal lobe and white matter abnormality in the left posterior cingulate, parahippocampal gyrus, thalamus, caudate, and bilateral precuneus. It revealed MCI-related decreased resting-state activity in the left superior temporal gyrus, right posterior cingulate/precuneus, and uncus and hyperactivation in the inferior parietal lobule and superior parietal lobule compared to HC. Task-related functional neuroimaging studies indicated MCI-related hypoactivation in the left inferior parietal lobule, right posterior cingulate, and bilateral precuneus and hyperactivation in the left middle frontal gyrus, superior parietal lobule, insula, superior temporal gyrus, and right inferior frontal gyrus. Conclusions: Via this ALE meta-analysis, we obtained these key regions suffering from different kinds of deficits in MCI. These regional abnormalities in MRI studies might serve as biomarkers for early diagnosis of MCI.